Jonathan Lai, Ph.D., professor of biochemistry at Einstein, engineers peptides, proteins, and antibodies into novel therapies and vaccines. In 2016, he helped develop the first antibodies that can potently neutralize the two deadliest ebolavirus strains. Most recently, he has published findings on a promising antibody therapy for infection by Chikungunya virus, a globally emerging mosquito-borne infection for which no vaccines or treatments yet exist. But he’s the first to admit that the business of science is not one of his strengths. Take a closer look.

NYU Langone Health and its Perlmutter Cancer Centerhave launched clinical whole-genome DNA methylation profiling for patients with brain tumors. This leading-edge molecular assay utilizes DNA epigenetic signatures and artificial intelligence with machine learning to correctly identify and subtype brain tumors. This leading-edge molecular assay utilizes DNA epigenetic signatures and artificial intelligence with machine learning to correctly identify and subtype brain tumors. Take a closer look.

A new multinational study shows that the most popular first-line treatment for hypertension is less effective and has more side effects than an alternative that’s prescribed much less often. The researchers, including Columbia’s George Hripcsak, MD, and Patrick Ryan, PhD, analyzed electronic health records and claims data from nearly 5 million patients who had begun drug treatment for hypertension. Take a closer look.

High-risk patients who have undergone a coronary stent procedure may not require long-term aspirin, according to a groundbreaking global study led by Roxana Mehran, MD, Director of the Center for Interventional Cardiovascular Research and Clinical Trials, Mount Sinai Heart, and the Mount Sinai Professor in Cardiovascular Clinical Research and Outcomes, Icahn School of Medicine at Mount Sinai. Take a closer look.

Education may reduce the risk of cognitive decline associated with the APOE e4 gene-the biggest genetic risk factor for late-onset Alzheimer’s disease-in older non-Hispanic black people, according to a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons. The study was published online in the Journal of Alzheimer’s Disease. Take a closer look.

Carlos Rodriguez of the Bronx seemed like a healthy, happy baby. But as his first birthday approached, he began to scream and cry at the slightest provocation. His “twos” were particularly terrible. While his peers were learning to talk, Carlos communicated only by grunting and pointing. Even worse, he would throw tantrums, banging his head against anything and everything. Take a closer look.

A set of powerful laboratory and computational techniques developed by scientists at Weill Cornell Medicine, the New York Genome Center (NYGC) and the Broad Institute will enable investigators to map the capacity of tumors to develop resistance to drugs and drug combinations. The techniques will allow researchers in principle to anticipate resistance mechanisms and suggest optimal drug doses and combinations across cancer types. Take a closer look.

A protein that breast, lung and other cancers use to promote their spread-or metastasis-to the brain, has been identified by a team led by Weill Cornell Medicine and New York-Presbyterian investigators. The protein, CEMIP, will now be a focus of efforts to predict, prevent and treat brain metastases, which are a frequent cause of cancer deaths. In their study, published Nov. 4 in Nature Cell Biology, the scientists found that CEMIP prompts blood vessel and resident immune cells in the brain to produce inflammatory molecules, which in turn support the survival and progression of cancer cells to form brain tumors. Take a closer look.

For the more than 1 million children attending New York City public schools, their choice of what to eat depends on which food sources are close to where they live. As measured in city blocks, proximity to fast and convenience food sellers can impact a student’s chances of becoming obese, according to a new study by researchers at NYU School of Medicine. Take a closer look.

The deleterious effects that obesity has on an individual’s health and the difficulty of reversing it in adults are well-known, ranging from diabetes and heart disease to cancer. For these reasons, obesity prevention in babies and children in populations at high risk is increasingly seen as a critical way to address the obesity epidemic. However, most studies on factors that contribute to obesity in very young children haven’t focused on the populations most at risk. Take a closer look.

Cells undergo natural aging and death, processes that impact a multitude of cellular factors. A new Stony Brook University-led study published online in PNAS, provides a biophysical model that reveals how damage accumulates in the shapes of cellular proteins with age and is a trigger to death. The finding opens a door to a better understanding of the molecular origins of age-related neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, which all entail protein damage. Take a closer look.

Victoria Frye, associate professor at the CUNY School of Medicineat The City College of New York, is leading the conversation on reducing intersectional stigmas at the community level to increase uptake of and adherence to biomedical HIV prevention modalities through a new grant from the National Institute of Mental Health. Take a closer look.

In this episode, we’re continuing our discussion of clinical trials. Part one of our series focused on what a clinical trial is, how clinical trials are organized, supported, and structured, and how these important studies help to advance and safeguard our health care. We also learned that clinical trials depend on people to enroll as study participants, a critical part of moving medicine forward that remains a great challenge for researchers. Take a closer look.

Government officials, local community leaders and other stakeholders joined New York Medical College (NYMC) on October 30 to celebrate a ribbon-cutting ceremony marking the five-year anniversary and expansion of BioInc@NYMC. The expansion of the fully-equipped biotechnology incubator adds an additional 9,500 square feet of new offices, conference rooms, shared-space desks and collaborative space. Since 2014, BioInc@NYMC has created more than 54 jobs, supported nine start-up companies, and with its newly expanded space, will allow for the incubation of up to 20 additional companies at the forefront of medical innovation. Take a closer look.

Investigates life-saving treatment for immune-compromised populations-Mitchell S. Cairo, M.D., professor of pediatrics, medicine, pathology, microbiology and immunology and cell biology and anatomy, and associate chair of the Department of Pediatrics at New York Medical College, received a four-year award totaling $1.7 million from the Food and Drug Administration (RO1 FD006363-01A1) to investigate safe and effective treatments for immune compromised patients with Epstein-Barr Virus (EBV), cytomegalovirus (CMV) or adenovirus (ADV). Take a closer look.

A rare, perfect score has been awarded by the National Institutes of Health (NIH) to a University at Buffalo professor who is leading a center designed to enhance care for older adults throughout Western New York. Bruce R. Troen, MD, professor of medicine and chief of the Department of Medicine’s Division of Geriatrics and Palliative Care in the Jacobs School of Medicine and Biomedical Sciences at UB and a physician with UBMD Internal Medicine, was awarded a $750,000 grant from the National Institute of Aging of the NIH. Take a closer look.