Role of osteocalcin outside of bone


Columbia University College Of Physicians and Surgeons


Gerard Karsenty, MD, PhD, the Paul A. Marks Professor of Genetics and Development, Professor of Medicine, and Chair of the Department of Genetics and Development at Columbia University College of Physicians & Surgeons


Karsenty’s research has uncovered that osteocalcin, a hormone that is released by bone, plays several important roles in human health. In a series of studies in mice, he found that osteocalcin helps to regulate blood sugar by stimulating the release of insulin into the bloodstream and improving the uptake of glucose in cells throughout the body. Karsenty also found that osteocalcin helps to regulate male fertility, brain development, and cognitive functions such as learning and memory.