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Noninflammatory changes of microglia are sufficient to cause epilepsy

Institution:

Albany Medical College

Researchers:

Yunfei Huang, MD, PhD.
Professor of Department of Neuroscience and Experimental Therapeutics

Impact:

Microglia are thought to be immune cells in the brain. It has long been postulated that excessive inflammatory response of microglia is the cause of epilepsy. However, my laboratory recently discovered that non-inflammatory changes in microglia causes severe seizures in our mouse model. Our finding points to a novel research direction toward better understanding how epilepsy occurs and how we develop new therapeutics for epilepsy.

*This work was recently highlighted in F1000Prime recommended By Long-Jun Wu and Ukpong B Eyo

Timeline:

The finding was published in Cell Reports, 2018

Topics

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Schools

Albany Medical CollegeAlbert Einstein College of MedicineCity University of New York School of MedicineColumbia University College Of Physicians and SurgeonsHofstra Northwell School of Medicine at Hofstra UniversityIcahn School of Medicine at Mount SinaiJacobs School of Medicine and Biomedical Sciences, the University at BuffaloNew York Institute of Technology College of Osteopathic MedicineNew York Medical CollegeNew York University School of MedicineSchool of Medicine and Dentistry at the University of Rochester Medical CenterStony Brook University School of MedicineSUNY Downstate Medical CenterSUNY Upstate Medical UniversityTouro College of Osteopathic MedicineWeill Cornell MedicineWeill Cornell Medicine, NewYork-Presbyterian