Noninflammatory changes of microglia are sufficient to cause epilepsy


Albany Medical College


Yunfei Huang, MD, PhD.
Professor of Department of Neuroscience and Experimental Therapeutics


Microglia are thought to be immune cells in the brain. It has long been postulated that excessive inflammatory response of microglia is the cause of epilepsy. However, my laboratory recently discovered that non-inflammatory changes in microglia causes severe seizures in our mouse model. Our finding points to a novel research direction toward better understanding how epilepsy occurs and how we develop new therapeutics for epilepsy.

*This work was recently highlighted in F1000Prime recommended By Long-Jun Wu and Ukpong B Eyo


The finding was published in Cell Reports, 2018