BCL6 oncogene


Columbia University College Of Physicians and Surgeons


Riccardo Dalla-Favera, MD, the Percy and Joanne Uris Professor of Clinical Medicine and professor of pathology and cell biology, genetics and development, and microbiology and immunology, Columbia University College of Physicians & Surgeons


In 1994, Dalla-Favera discovered this oncogene, a transcription factor that is involved in diffuse large B-cell lymphoma (DLBL), the most common type of non-Hodgkin lymphoma. Subsequently, Dalla-Favera and his team developed a mouse model containing a BCL6 mutation, showing the role of the gene in the pathogenesis of DLBL. The mouse model may be instrumental in developing new therapies for the disease.