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BCL6 oncogene

Institution:

Columbia University College Of Physicians and Surgeons

Researchers:

Riccardo Dalla-Favera, MD, the Percy and Joanne Uris Professor of Clinical Medicine and professor of pathology and cell biology, genetics and development, and microbiology and immunology, Columbia University College of Physicians & Surgeons

Impact:

In 1994, Dalla-Favera discovered this oncogene, a transcription factor that is involved in diffuse large B-cell lymphoma (DLBL), the most common type of non-Hodgkin lymphoma. Subsequently, Dalla-Favera and his team developed a mouse model containing a BCL6 mutation, showing the role of the gene in the pathogenesis of DLBL. The mouse model may be instrumental in developing new therapies for the disease.

Timeline:

1994-2005

Topics

AgingBasic ScienceCancerCardiovascularClinical ResearchDiagnosticsDrug DevelopmentFeaturedGeneticsImmune SystemInfectious DiseaseMedical DeviceMental HealthNeurodegenerativeNobel PrizePediatricsPublic HealthRespiratorySurgical AdvancementTechnologyTreatment AdvancesVaccines

Schools

Albany Medical CollegeAlbert Einstein College of MedicineCity University of New York School of MedicineColumbia University College Of Physicians and SurgeonsHofstra Northwell School of Medicine at Hofstra UniversityIcahn School of Medicine at Mount SinaiJacobs School of Medicine and Biomedical Sciences, the University at BuffaloNew York Institute of Technology College of Osteopathic MedicineNew York Medical CollegeNew York University School of MedicineSchool of Medicine and Dentistry at the University of Rochester Medical CenterStony Brook University School of MedicineSUNY Downstate Medical CenterSUNY Upstate Medical UniversityTouro College of Osteopathic MedicineWeill Cornell MedicineWeill Cornell Medicine, NewYork-Presbyterian