Weill Cornell Medicine: Dean’s Symposium on Entrepreneurship and Academic Drug Development Highlights Weill Cornell Medicine’s Expanding Entrepreneurial Ecosystem
Dr. Juan Cubillos-Ruiz was just five years out of grad school and an assistant professor at Weill Cornell Medicine when he had an idea for a novel cancer treatment. In 2015, he discovered that many tumors effectively shut down the antitumor activity of nearby immune cells by hijacking a signaling pathway in the cells called the ER stress pathway, keeping it chronically activated. An inhibitor that blocked that pathway would switch off the aberrant ER stress signaling, restoring antitumor immunity. With promising early results in mouse models of cancer, Dr. Cubillos-Ruiz set out to spin his findings into biotech gold and a treatment that might be a life-saver for many cancer patients. Learn more.