Dennis S. Charney, MD, is a preeminent expert in neurobiology who has made fundamental contributions to the understanding of human anxiety, fear, depression, and resilience. He has played a key role in the discovery of new treatments for mood and anxiety disorders, and remains a continual champion of rigorous, translational scientific efforts to improve patient care. Dr. Charney is Anne and Joel Ehrenkranz Dean of the Icahn School of Medicine at Mount Sinai and President for Academic Affairs for the Mount Sinai Health System. By recruiting exceptional faculty across the biomedical sciences, as well as in computational biology, genetics, artificial intelligence, information technology, and entrepreneurship, Dr. Charney has cultivated a supercharged, Silicon Valley-style atmosphere at Icahn Mount Sinai. Under his leadership, the School has emerged as a global leader in medical education. Dr. Charney’s commitment to hiring faculty who are innovative and ambitious researchers—as well as dedicated educators—is reflected by the fact that Icahn Mount Sinai is consistently among the nation’s top recipients of National Institute of Health funding. Early in his tenure as Dean, Dr. Charney unveiled a strategic plan that laid the foundation for the dozens of research institutes that Mount Sinai is known for today. Within and across these hubs of scientific and clinical enterprise, renowned scientists and physicians facilitate the development of effective treatments for the most serious medical conditions. By welcoming students into these institutes to work and study with such faculty, Icahn Mount Sinai prepares future researchers and clinicians to continually challenge the limits of science and medicine. This strategic plan is updated every year. Most recently, there have been major investments in genetics, including the Mount Sinai Million project, Immunology, including the establishment of a new department of Immunology and Artificial Intelligence (AI), including the establishment of the first department of AI and Human Health. Dr. Charney is considered one of the most innovative researchers in psychiatry. His research with colleagues at Yale, the National Institute of Mental Health, and Mount Sinai has led to more rapid treatments for treatment resistant depression (lithium augmentation; ketamine), Post Traumatic Stress Disorder (Ketamine), Rapid treatment for opioid withdrawal (clonidine and naloxone), rapid treatment of panic disorder (clonazepam and sertraline), and the first digital treatment for depression (emotional face memory task). His research on resilience has led to approaches to enhance human resilience to stress and trauma. The work demonstrating that ketamine is a rapidly acting antidepressant has been hailed as one of the most exciting developments in antidepressant therapy in more than half a century. A prolific author, Dr. Charney has written or co-authored more than 800 publications, including groundbreaking scientific papers, chapters, and books. His studies on human resilience, which identified ten key resilience factors for building the strength to bounce back from stress and trauma, are summarized in the celebrated Resilience: The Science of Mastering Life’s Greatest Challenges (3rd ed.). Co-authored with Steven Southwick and Jonathan DePierro, the newest edition was published by Cambridge University Press, September 2023.