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Biomedical Research News from AMSNY: August 2023

Aug
29
2023

Highlights

Weill Cornell Medicine: Large PCORI Award Funds Comparative Study of Surgical Options for Coronary Artery Disease in Underrepresented Patient Populations
 
A multi-institutional team of scientists led by Dr. Mario Gaudino, the Stephen and Suzanne Weiss Professor in Cardiothoracic Surgery and assistant dean for clinical trials at Weill Cornell Medicine, has been approved for a nearly $30 million funding award from the Patient-Centered Outcomes Research Institute (PCORI). The award will fund the first study among women and Black and Hispanic patients comparing the effectiveness of two revascularization options used to treat coronary artery disease. Learn more.
Icahn School of Medicine at Mount Sinai Receives $11.5 Million Grant Renewal to Study the Impact of Psychosocial Stress on Cardiovascular Disease
 
Psychosocial stress profoundly affects people’s lives globally, not least because it can be a critical risk factor for cardiovascular disease. Thanks to an $11.5 million award renewal from the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health, distinguished researchers at the Icahn School of Medicine at Mount Sinai and elsewhere aim to gain a deeper understanding of how stress influences cardiovascular health. Learn more.

COVID-19

University of Rochester School of Medicine & Dentistry Study Shows Surprisingly Low Use of COVID Antiviral Treatments in Nursing Homes
 
Nursing homes were a key battleground during the COVID pandemic and prioritized for distribution of PPE, vaccines, and COVID testing kits. However, new research shows that monoclonal antibodies and oral antiviral drugs were not used in these facilities as much as would be expected given the high-risk of resident populations. Learn more.

Cancer

NYU Grossman School of Medicine: Diversity Plays a Key Role in Black Americans’ Trust of Videos About Prostate Cancer
 
Black Americans are 1.6 times more likely to believe medical information presented by a Black physician or patient as compared with information presented by a White speaker, a new study shows. This finding, the authors say, highlights the importance of increasing racial diversity among healthcare providers to improve healthcare discussions with minority populations. Learn more.
New York Medical College: New Non-Invasive Test Can Detect Oral and Throat Cancer at Early Stages
 
When detected early oral cancer has a high survival rate, but most cases are not detected until the disease is very advanced. A new saliva-based, non-invasive test, CancerDetect for Oral & Throat Cancer™ [CDOT], developed by VIOME life sciences and tested by a group of researchers from around the world, including Salomon Amar, Ph.D., D.D.S., vice president for research at New York Medical College, senior vice president for biomedical research at Touro University and professor of pharmacology and of pathology, microbiology and immunology, has the potential to enable early diagnosis, saving lives and significantly reducing health care expenditures. Learn more.
NYU Grossman School of Medicine: Perlmutter Cancer Center’s Center for Blood Cancers Awards Inaugural Pilot Grants Supporting Translational Research
 
Advances in the treatment of leukemia have improved the outlook for people with these blood cancers, but new therapeutic approaches that target unique aspects of leukemia cells are needed. To this end, the Center for Blood Cancers, part of NYU Langone Health’s Perlmutter Cancer Center, has awarded its first pilot project grants to encourage path-breaking translational or preclinical blood cancer research. Learn more.
Jacobs School of Medicine & Biomedical Sciences at University at Buffalo: With her first R01, Junior Faculty Member at UB is Exploring What Drives Drug Resistance in Prostate Cancer
 
Remi Adelaiye-Ogala, PhD, knows that choosing a career in science requires a thick skin. An assistant professor of medicine in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, Adelaiye-Ogala is familiar with the ups and downs of competing for grants and peer review, not to mention the uncertainties of microscopic worlds that don’t yield their secrets easily. Learn more.

Neurology

University of Rochester School of Medicine & Dentistry: Trading Sickness for Health: Swapping Brain Cells Points to New Huntington’s Therapies
 
New research appearing in the journal Nature Biotechnology answers important questions about the viability of treatments that seek to replace diseased and aged cells in the central nervous system with healthy ones. Its findings have implications for a number of neurological and psychiatric disorders—including Huntington’s disease, amyotrophic lateral sclerosis (ALS), and schizophrenia—that have been linked to glia, a population of cells that support brain health and function. Learn more.
Weill Cornell Medicine: Potential Neuropathic Pain Treatment Shows Promise in Preclinical Tests
 
A non-opioid designer molecule for treating chronic neuropathic pain by calming hyperactive pain-sensing neurons in the peripheral nervous system has had promising results in a preclinical study conducted by researchers at Weill Cornell Medicine and the Burke Neurological Institute. In the study, published Aug. 2 in the British Journal of Anaesthesia, the first-in-class drug conceptualized by lead author Dr. Gareth Tibbs was found to function according to its design at both the molecular level and as an apparently side-effect-free pain reliever in rats. Learn more.

More Studies

Albert Einstein College of Medicine: Translating Discoveries Into Therapies
 
Moving basic-science discoveries out of the lab and into clinical trials isn’t easy. Just ask Steven Almo, Ph.D., professor and chair of biochemistry at Einstein. In 2011, he came up with an idea for a new form of immunotherapy, known as Immuno-STAT™, that didn’t enter clinical trials until 2019. Learn more.
Columbia University Vagelos College of Physicians and Surgeons: Why Do Some People Succeed in Maintaining Weight Loss?
 
For many people trying to lose weight, shedding pounds is the easy part. Keeping the pounds off over time is usually the hard part, and most people regain weight. What makes some succeed in maintaining weight loss for the long haul? Learn more.
Jacobs School of Medicine & Biomedical Sciences at University at Buffalo: A Clinic in Buffalo is Detecting—and Treating—Hepatitis C Virus in Infants
 
A pediatric infectious disease team led by University at Buffalo faculty is screening and treating hepatitis C virus (HCV)-exposed infants. The clinic’s efforts are documented in a new paper based on an 11-year retrospective chart review, published this month in BMC Gastroenterology. Learn more.
Albert Einstein College of Medicine: Poor Air Quality Leads to Longer Hospital Stays for Children with Asthma, According to New Research
 
Children with asthma spend more time in the hospital when there is a greater amount of particulate matter (PM 2.5) – tiny pieces of solids or liquids – and Ozone (O3) – a colorless gas – in the air, according to a new study by researchers at the Children’s Hospital at Montefiore (CHAM). The study, just published in the Journal of Asthma, comes days after New York City was blanketed in wildfire smoke. Learn more.
Columbia University Vagelos College of Physicians and Surgeons: These Bones Were Made for Walking
 
Perhaps the most profound advance in primate evolution occurred about 6 million years ago when our ancestors started walking on two legs. The gradual shift to bipedal locomotion is thought to have made primates more adaptable to diverse environments and freed their hands to make use of tools, which in turn accelerated cognitive development. With those changes, the stage was set for modern humans. Learn more.

Student Research

New York Medical College: Obstetrics and Gynecology Summer Research Program Results in Expanded Research Opportunities for Students
 
The Obstetrics and Gynecology Summer Research Program at New York Medical College marked another successful year this July with more than 20 medical students participating in team research projects on a wide variety of obstetrics and gynecology-related topics, including treatment for pudendal neuralgia, hypertension in pregnancy, sarcopenia among cervix cancer patients and understanding patient perspectives about vaginal estrogen. Now in its third year, the program has led to both publications in academic journals and numerous presentations at national conferences for program participants. Learn more.

Faculty & Events

New York Institute of Technology College of Osteopathic Medicine Staff Profile: Alexis Perez
 
“My mom said ‘why’ was my favorite word when I was younger,” says Alexis Perez, a research associate in the Department of Biomedical Sciences at the College of Osteopathic Medicine. “That word stuck with me throughout my life and is a critical question in my field.” A self-described “curious person” who asks many questions in order to understand how things work, Perez has an extensive background in the sciences. Learn more.

Awards & Grants

Albany Medical College: $2.1 M NIH Grant Awarded for Study of Tuberculosis
 
Albany Medical College scientists have been awarded a four-year, $2.1 million grant from the National Institutes of Health (NIH) to study the role of lung epithelial cells – the cells that form a mucosal barrier in the lungs – in protecting against tuberculosis (TB). Learn more.
New York Institute of Technology College of Osteopathic Medicine Biomedical Researchers Secure Prestigious Federal Grants
 
This summer, several faculty from the College of Osteopathic Medicine’s (NYITCOM) Department of Biomedical Sciences have secured federal grants in support of their impressive research projects. The awards, which total approximately $1.4 million (as of July 1, 2023), include NYITCOM’s first grant from the United States Department of Defense (DoD) and two competitive grants from the National Institutes of Health (NIH). Learn more.
Renaissance School of Medicine at Stony Brook University: LILAC Grant Enables Purchase of Key Instruments to Assess Lipid Regulation in Cancer
 
Daniel Canals, PhD, Research Assistant Professor at the Stony Brook Cancer Center, has received a grant from the Long Island League to Abolish Cancer (LILAC) for the purchase of two cutting-edge instruments that enable him and colleagues to better understand how lipids are regulated in cancer, and in turn, the many functions that lipids perform in cancer cells. Learn more.
Icahn School of Medicine at Mount Sinai Fellow Salman E. Qasim, PhD, Awarded Prestigious Essay Prize From Lasker Foundation
 
The Lasker Foundation announced that Salman E. Qasim, PhD, a postdoctoral fellow at the Icahn School of Medicine at Mount Sinai, is among five winners of its 10th annual Lasker Essay Contest. The winning submissions were selected from hundreds of essays penned by biomedical graduate students and health professions trainees from 25 countries. Dr. Qasim’s essay, titled “The Human Brain: The Final Frontier, and the Wild West,” was published in The Journal of Clinical Investigations and on the Lasker Foundation website. Learn more.

More News

Renaissance School of Medicine at Stony Brook University: SBSH Opens Regional Tick-Borne Disease Center in Hampton Bays, the First and Only Dedicated Tick Clinic in the Northeast
 
Stony Brook Southampton Hospital’s Regional Tick- Borne Disease Center will open on Monday, August 14 in the Hampton Bays Atrium and is clinically supported by physicians from Stony Brook Medicine’s Meeting House Lane Medical Practice and Stony Brook Children’s Hospital. This on-site dedicated team of infectious disease specialists will treat children and adults for tick bites and diagnose tick-borne illnesses, by appointment only. Learn more.

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