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Newsletter > Biomedical Research News from AMSNY: April 2023

04/28/2023

Biomedical Research News from AMSNY: April 2023

Highlights

Rochester Democrat and Chronicle Op-Ed: Support Funding to Attract Medical Talent
 
State Assemblymember Harry Bronson and State Senator Jeremy Cooney talk about the importance of NYFIRST, a program that supports the recruitment and retention of world-class scientific talent at New York State’s 17 medical schools. University of Rochester, SUNY Upstate Medical University, Columbia University, and Icahn School of Medicine at Mount Sinai, among others, have received funding from the program, which was designed by Empire State Development with input from the Associated Medical Schools of New York. The program is used to upgrade lab spaces, purchase equipment and hire support staff. Learn more.
New York Medical College Study Addresses Disparities in Women and Diverse Racial and Ethnic Groups in Radiation Oncology
 
Though the diversity of the United States continues to grow, the disparity of women and people from racial and ethnic groups underrepresented in medicine pursuing careers in the field of radiation oncology persists. A recent study conducted by New York Medical College faculty and students and published in Advances in Radiation Oncology demonstrated that medical students showed little to no difference in considering radiation oncology as a specialty across races and ethnicities, making more education and exposure to opportunities in radiation oncology and further research into barriers to entry into the field paramount to addressing these inequities in the future. Learn more.

COVID-19

Weill Cornell Medicine Study Identifies Human Genes Enabling SARS-CoV-2 Infection
 
The activity of a gene called CIART is a key factor in the establishment of the viral infection that causes COVID-19, according to a study from researchers at Weill Cornell Medicine and New York University Grossman School of Medicine. In the study, which appears March 13 in Nature Cell Biology, the researchers used multiple models of human organs, called organoids, to search for general host factors that influence infections by SARS-CoV-2, the coronavirus that causes COVID-19. Learn more.
University of Rochester School of Medicine & Dentistry: Frequent COVID Testing of Nursing Home Staff Protected Residents, Saved Lives
 
A new study, appearing today in the New England Journal of Medicine, shows that nursing homes that conducted staff surveillance testing more regularly experienced significantly lower rates of COVID infections and deaths among residents. “Testing is a key part of any infectious disease response, surveillance testing in particular,” said Brian McGarry, Ph.D., an assistant professor of Medicine and Public Health Sciences at the University of Rochester Medical Center, and lead author of the study. Learn more.

Cancer

Norton College of Medicine at Upstate Medical University Study Links Ingredient in Sweeteners to Liver Cancer
 
Research conducted at SUNY Upstate Medical University and recently published in Nature Metabolism found that commonly used sweeteners may cause cancer, and also that it may be possible to prevent the growth of cancer with medication. Liver cancer is the fifth most common cancer and the third leading cause of cancer-related death worldwide. In a study conceived and designed by SUNY Distinguished Professor Andras Perl, MD, PhD, researchers studied how mice with a genetic mutation also found in humans progress from cirrhosis to liver cancer. Learn more.
New York Institute of Technology College of Osteopathic Medicine Study: Spice May Improve Ovarian Cancer Treatment
 
NYITCOM Associate Professor of Clinical Sciences Maria Pino, Ph.D., has co-authored a new research paper that makes a strong case for why a golden spice commonly found in curry could enhance ovarian cancer treatments. Ovarian cancer is the second most common gynecological cancer among women in the United States, with an estimated 20,000 women in America expected to receive a new diagnosis of ovarian cancer this year. Learn more.

Cardiology

NYU Grossman School of Medicine: Alert Banners Dramatically Increase Prescribing Rates of Lifesaving Heart Failure Medication
 
An automated system that flags the patients who could most benefit from an underused yet lifesaving cardiology drug more than doubled new prescriptions, according to a pilot program test by researchers at NYU Grossman School of Medicine. “Our findings suggest that tailored electronic notifications can boost the prescription of lifesaving drugs,” said study lead author and cardiologist Amrita Mukhopadhyay, MD, a clinical instructor in the Department of Medicine. Learn more.
Icahn School of Medicine at Mount Sinai: Yellow III Trial Finds That Lipid Lowering With a PCSK9 Inhibitor Could Benefit Heart Patients on Statin Therapy
 
Even after high-intensity statin therapy, a considerable residual risk exists for heart attack and stroke among adults with coronary artery disease (CAD). A clinical study led by Mount Sinai offers strong evidence that aggressive lipid lowering with a proprotein convertase subtilisin kexin type 9 inhibitor (PCSK9i), along with a statin, can significantly reduce that threat and potentially help doctors identify patients who would benefit most from intensification of treatment to change their coronary plaque morphology and composition. Learn more.

Neurology

University of Rochester School of Medicine & Dentistry: Common Dry Cleaning Chemical Linked to Parkinson’s Disease
 
A common and widely used chemical may be fueling the rise of the world’s fastest growing brain condition–Parkinson’s disease. For the past 100 years, trichloroethylene (TCE) has been used to decaffeinate coffee, degrease metal, and dry clean clothes. It contaminates the Marine Corps base Camp Lejeune, 15 toxic Superfund sites in Silicon Valley, and up to one-third of groundwater in the U.S. TCE causes cancer, is linked to miscarriages and congenital heart disease, and is associated with a 500 percent increased risk of Parkinson’s disease. Learn more.
New York Institute of Technology College of Osteopathic Medicine Q&A: Causes, Challenges, and Treatments for Parkinson’s
 
Every six minutes, a person in the United States will be diagnosed with Parkinson’s disease, a neurodegenerative disorder that affects the nervous system and the parts of the body controlled by the nerves. Approximately one million Americans today are living with Parkinson’s. April is observed as Parkinson’s Awareness Month in honor of the birth month of James Parkinson, the London physician who first identified the disease in 1817. Learn more.
Weill Cornell Medicine: Tiny Eye Movements Are Under a Surprising Degree of Cognitive Control
 
A very subtle and seemingly random type of eye movement called ocular drift can be influenced by prior knowledge of the expected visual target, suggesting a surprising level of cognitive control over the eyes, according to a study led by Weill Cornell Medicine neuroscientists. The discovery, described Apr. 3 in Current Biology, adds to the scientific understanding of how vision—far from being a mere absorption of incoming signals from the retina—is controlled and directed by cognitive processes. Learn more.
Columbia University Vagelos College of Physicians and Surgeons: Alzheimer’s: New Study Supports Amyloid Hypothesis but Suggests Alternative Treatment
 
An analysis of human brain cells provides new evidence in support of the “amyloid hypothesis,” the prevailing idea that Alzheimer’s is caused by the accumulation of beta-amyloid proteins in the brain. In the study, Columbia University researchers found that amyloid sparks an alliance between two proteins in the brain’s neurons and this pairing is linked to about half of the gene changes that are known to occur in the disease, triggering the rapid accumulation of tau proteins, a primary driver of neurodegeneration in the disease. Learn more.

More Studies

Renaissance School of Medicine at Stony Brook University: Can Controlling Retinoic Acid Be a Key to Preventing Infections in the Gut?
 
A team of scientists from the Renaissance School of Medicine (RSOM) at Stony Brook University have identified a distinct role of retinoic acid, a metabolite of vitamin A, during the immune response of the gut. This finding, detailed in a paper published in the Journal of Experimental Medicine, and highlighted in a broader piece in the journal, could help lead to ways to control the retinoic acid response and therefore be used as a therapy or for vaccine development against infection or even to treat GI tumors. Learn more.
NYU Grossman School of Medicine: Genes That Form Specific Bones in the Womb Heal Them Later in Life
 
Genes long known to control the formation of bones before birth also control bone healing later in life, a new study found. Led by researchers at NYU Langone Health, a new study pinpointed key Hox genes, specific to each location in the body, as the controllers of stem cells involved in both forming and repairing bone. Learn more.
Renaissance School of Medicine at Stony Brook University: Students Who Threaten Violence Often Have Psychiatric or Learning Disorders
 
While previous studies have focused upon identifying potential school shooters, little is known about the mental health and associated characteristics of students who make threats in schools. A study by a team of Stony Brook child psychiatry experts uncovers the wide range of psychiatric diagnoses, learning disorders, educational and treatment needs of this population. The findings are published early online in a paper in the Journal of the American Academy of Child & Adolescent Psychiatry. Learn more.
Jacobs School of Medicine & Biomedical Sciences at University at Buffalo: No Brain, No Gain When Relieving Chronic Pain
 
Studies have shown that a specific non-drug treatment of cognitive behavioral therapy (CBT) developed by researchers at the Jacobs School of Medicine and Biomedical Sciences can be effective for a range of pain problems and lead to significant improvements in functioning, quality of life and symptoms resistant to medical treatments. Learn more.
Icahn School of Medicine at Mount Sinai: Genetic Causes of Three Previously Unexplained Rare Diseases Identified
 
Using a new computational approach they developed to analyze large genetic datasets from rare disease cohorts, researchers at the Icahn School of Medicine at Mount Sinai and colleagues have discovered previously unknown genetic causes of three rare conditions: primary lymphedema (characterized by tissue swelling), thoracic aortic aneurysm disease, and congenital deafness. The work was done in collaboration with colleagues at the University of Bristol, UK; KU Leuven, Belgium; the University of Tokyo; the University of Maryland; Imperial College London, and others from around the world. Learn more.

Student Research

New York Medical College: First-Year Gross Anatomy Experience at New York Medical College Yields Study Publications for Medical Students
 
Several medical students at New York Medical College gained more than just hands-on experience in the gross anatomy lab during their first year of medical school. They also had the opportunity to impact future medical practice with the recent publications of case studies on Petit’s (inferior lumbar) hernia in the Medical Student Research Journal and on renal and gonadal vasculature in the International Journal of Medical Students. Learn more.

Awards & Grants

Norton College of Medicine at Upstate Medical University: Working to Help Transplant Patients, Upstate Researcher Awarded $3.2 Million Grant to Help Create Treatment to Fight HCMV Infection
 
Gary Chan, PhD has been awarded a five-year $3.2 million grant National Institute of Allergies and Infectious Diseases to find a treatment for one of the most dangerous infections for transplant recipients. Chan, an associate professor of microbiology and immunology at SUNY Upstate Medical University, said his lab is focused on studying host-pathogen interactions involving human cytomegalovirus (HCMV) and understanding how HCMV-mediated alterations to cellular function lead to human disease. Learn more.
Columbia University Vagelos College of Physicians and Surgeons: Transition to Parenthood Center Established with Funding from Bezos Family Foundation
 
With a transformational gift from the Bezos Family Foundation, Columbia University will launch the Center for the Transition to Parenthood in the Department of Obstetrics & Gynecology. Supported by the most advanced scientific knowledge in the field, the center seeks to reinvent prenatal care, address the mental health of parents, improve the overall health of infants, and promote family well-being. Learn more.

More News

Jacobs School of Medicine & Biomedical Sciences at University at Buffalo and Instacart Partner on Project Designed to Make it Easier for Families to Eat Healthy
 
University at Buffalo researchers who study what makes people buy and eat healthy foods are teaming up with Instacart, the leading grocery technology company in North America, to test nutrition intervention programs for families at higher risk for obesity. Their upcoming project aims to enroll 70 families, about half of whom will be low-income. Learn more.

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