Neuromodulation in Parkinson’s disease and Epilepsy


Albany Medical College


Damian Shin, MSc PhD
The Department of Neuroscience and Experimental Therapies at Albany Medical College


Shin has investigated various aspects of deep brain stimulation (DBS) for Parkinson’s disease (PD) andepilepsy spanning topics from elucidating its underlying mechanism(s) to identifying novel DBS targets. Specifically, he reported that extracellular ion homeostasis is altered with DBS which could contribute to DBS therapeutic efficacy by affecting neural activity; DBS can engage parallel motor circuits to improve PD symptomology; stimulating a brain area called the substantia nigra reticulata improved motor function in PD and DBS dampened painful mechanical and thermal sensations by activating a top-down control of pain mechanism in PD. For epilepsy, Shin showed that electrically stimulating a brain area called the ventral pallidum could prevent partial and generalized seizures. With electrophysiological recordings, he found that ventral pallidum DBS increased inhibitory signaling from the ventral pallidum to connected brain structures in the forebrain, midbrain and brainstem for seizure control.


Dr. Shin has been studying and using deep brain stimulation since 2005.