Hyaluronidases are a family of six enzymes discovered in the Human Genome and identified for the first time. This was accomplished in a coordinated approach using enzyme chemistry, cell biology, and bioinformatics


Touro College of Osteopathic Medicine


Robert Stern, MD, Touro College of Osteopathic Medicine, Professor of Pathology in the Department of Basic Biomedical Sciences.


These enzymes have a major impact in embryology, cancer progression, stem cell biology, disease diagnostics, wound healing, and in tissue repair and regeneration.



Studies on the hyaluronidases, previously a family of neglected enzymes, began in 1995 by first establishing new techniques for their assay, and devising a chromatographic procedure for their isolation. This was followed by their expression, sequencing, and characterization between 2000-2005. There are two groups of three enzymes each on two chromosomal locations. Over 100 publications in major journals have resulted from these efforts.