Institution:Touro College of Osteopathic Medicine
Robert Stern, MD, Touro College of Osteopathic Medicine, Professor of Pathology in the Department of Basic Biomedical Sciences.
These enzymes have a major impact in embryology, cancer progression, stem cell biology, disease diagnostics, wound healing, and in tissue repair and regeneration.
Studies on the hyaluronidases, previously a family of neglected enzymes, began in 1995 by first establishing new techniques for their assay, and devising a chromatographic procedure for their isolation. This was followed by their expression, sequencing, and characterization between 2000-2005. There are two groups of three enzymes each on two chromosomal locations. Over 100 publications in major journals have resulted from these efforts.