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Hyaluronidases are a family of six enzymes discovered in the Human Genome and identified for the first time. This was accomplished in a coordinated approach using enzyme chemistry, cell biology, and bioinformatics

Institution:

Touro College of Osteopathic Medicine

Researchers:

Robert Stern, MD, Touro College of Osteopathic Medicine, Professor of Pathology in the Department of Basic Biomedical Sciences.

Impact:

These enzymes have a major impact in embryology, cancer progression, stem cell biology, disease diagnostics, wound healing, and in tissue repair and regeneration.

 

Timeline:

Studies on the hyaluronidases, previously a family of neglected enzymes, began in 1995 by first establishing new techniques for their assay, and devising a chromatographic procedure for their isolation. This was followed by their expression, sequencing, and characterization between 2000-2005. There are two groups of three enzymes each on two chromosomal locations. Over 100 publications in major journals have resulted from these efforts.

Topics

AgingBasic ScienceCancerCardiovascularClinical ResearchDiagnosticsDrug DevelopmentFeaturedGeneticsImmune SystemInfectious DiseaseMedical DeviceMental HealthNeurodegenerativeNobel PrizePediatricsPublic HealthRespiratorySurgical AdvancementTechnologyTreatment AdvancesVaccines

Schools

Albany Medical CollegeAlbert Einstein College of MedicineCity University of New York School of MedicineColumbia University College Of Physicians and SurgeonsHofstra Northwell School of Medicine at Hofstra UniversityIcahn School of Medicine at Mount SinaiJacobs School of Medicine and Biomedical Sciences, the University at BuffaloNew York Institute of Technology College of Osteopathic MedicineNew York Medical CollegeNew York University School of MedicineSchool of Medicine and Dentistry at the University of Rochester Medical CenterStony Brook University School of MedicineSUNY Downstate Medical CenterSUNY Upstate Medical UniversityTouro College of Osteopathic MedicineWeill Cornell MedicineWeill Cornell Medicine, NewYork-Presbyterian