High-dose anticholinergic therapy for torsion dystonia


Columbia University College Of Physicians and Surgeons


Robert E. Burke, MD, the Alfred and Minnie Bressler Professor of Neurology, and Stanley Fahn, MD, the H. Houston Merritt Professor of Neurology at Columbia University College of Physicians & Surgeons


Torsion dystonia is a movement disorder that causes sustained, twisting involuntary movements. A severe form in children causes incapacitating, generalized muscle spasms.  Before the use of high-dose trihexyphenidyl, there was no established therapy for the condition. Burke, Fahn, and colleagues led a clinical trial demonstrating that high-dosage anticholinergic therapy with trihexyphenidyl produced significant, sustained benefit for most patients. Anticholinergics remain a mainstay of treatment of this condition.