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Evaluation of transcatheter aortic valve replacement (TAVR) versus open heart surgery

Institution:

Columbia University College Of Physicians and Surgeons

Researchers:

Craig Smith, MD, Chair of the Department of Surgery, and Martin Leon, MD, professor of medicine, Columbia University College of Physicians & Surgeons

Impact:

Smith and Leon were co-lead investigators of a series of clinical trials (Placement of AoRTic TraNscatherER valves, or PARTNER) to evaluate the safety and efficacy of a minimally invasive approach to aortic valve replacement, known as TAVR. In PARTNER I, the researchers showed that TAVR was a safe and effective therapy for patients with severe narrowing of the aortic artery who are not candidates for surgery, or are at high risk for surgical complications. PARTNER II extended these benefits to patients with intermediate risk for surgical complications. Both studies were published in New England Journal of Medicine.

Timeline:

2011-2016

Topics

AgingBasic ScienceCancerCardiovascularClinical ResearchDiagnosticsDrug DevelopmentFeaturedGeneticsImmune SystemInfectious DiseaseMedical DeviceMental HealthNeurodegenerativeNobel PrizePediatricsPublic HealthRespiratorySurgical AdvancementTechnologyTreatment AdvancesVaccines

Schools

Albany Medical CollegeAlbert Einstein College of MedicineCity University of New York School of MedicineColumbia University College Of Physicians and SurgeonsHofstra Northwell School of Medicine at Hofstra UniversityIcahn School of Medicine at Mount SinaiJacobs School of Medicine and Biomedical Sciences, the University at BuffaloNew York Institute of Technology College of Osteopathic MedicineNew York Medical CollegeNew York University School of MedicineSchool of Medicine and Dentistry at the University of Rochester Medical CenterStony Brook University School of MedicineSUNY Downstate Medical CenterSUNY Upstate Medical UniversityTouro College of Osteopathic MedicineWeill Cornell MedicineWeill Cornell Medicine, NewYork-Presbyterian