Evaluation of transcatheter aortic valve replacement (TAVR) versus open heart surgery


Columbia University College Of Physicians and Surgeons


Craig Smith, MD, Chair of the Department of Surgery, and Martin Leon, MD, professor of medicine, Columbia University College of Physicians & Surgeons


Smith and Leon were co-lead investigators of a series of clinical trials (Placement of AoRTic TraNscatherER valves, or PARTNER) to evaluate the safety and efficacy of a minimally invasive approach to aortic valve replacement, known as TAVR. In PARTNER I, the researchers showed that TAVR was a safe and effective therapy for patients with severe narrowing of the aortic artery who are not candidates for surgery, or are at high risk for surgical complications. PARTNER II extended these benefits to patients with intermediate risk for surgical complications. Both studies were published in New England Journal of Medicine.