A new DNA sequencing method, called Maximum Depth Sequencing (MDS)


New York University School of Medicine


Evgeny A. Nudler, PhD, NYU School of Medicine


The MDS method eliminates the error introduced by core methods behind current high-speed DNA sequencing machine.

MDS is a new high-throughput DNA sequencing method that is ultra-sensitive and can detect rare sequence variants in genomic DNA. This new method enables the detection of extremely rare mutations that occur in bacteria, which is important for understanding basic evolutionary processes and of potential value in various clinical settings, such uncovering bacterial mechaisms that lead to the development of antibiotic resistance.

Pubmed citation:
Rates and mechanisms of bacterial mutagenesis from maximum-depth sequencing.
Jee J, Rasouly A, Shamovsky I, Akivis Y, Steinman SR, Mishra B, Nudler E.
Nature. 2016 Jun 30;534(7609):693-6. PMID: 27338792